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In a single-dose, four-period replicate crossover design study, comparing two 500 mg metformin hydrochloride extended-release tablets to one 1,000 mg metformin hydrochloride extended-release tablet administered in the evening with food to 29 healthy male subjects, two 500 mg metformin hydrochloride. I guess this shouldnt come as a total surprise. Contraindications Metformin hydrochloride extended-release tablets are contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m2) see Warnings and Precautions (5.1). This second option is called a "comparative bioavailability" study. They say that the tumor itself does not cause this. An overdose of prednisone is not expected to produce life threatening symptoms. Gender Metformin pharmacokinetic parameters did not differ significantly between normal subjects and patients with type 2 diabetes mellitus when analyzed according to gender (males19, females16). 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